you already mentioned some issues with c2dx like faulty desktop support, differences between platforms and faulty UI components.
V-Play does not have these limitations, and has many more advantages over c2dx. These are summarized here.
The most important I think is the time you save with developing with V-Play: QML is a declarative language that allows about 70% code savings compared to c2dx, while having the same performance!
At the link above, you can see side-by-side comparisons of c2dx and V-Play code as well as a complete project written in c2dx and V-Play that amplifies this benefit.
Also, this was the result of a survey about cross-platform tools by more than 2,000 developers globally. Cocos2d was in this survey as well, the results prove my last points..
Which tools did you use to create your isometric game levels? Did you use Tiled, another 3rd party level editor or did you write a custom level editor?